Improved synthesis of an ester-type prodrug, 1-acetoxyethyl 7-((Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-((Z)-1-propenyl)-3-cephem-4-carboxylate (BMY-28271).
نویسندگان
چکیده
منابع مشابه
Improved synthesis of an ester-type prodrug, 1-acetoxyethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[(Z)-1- propenyl]-3-cephem-4-carboxylate (BMY-28271).
1-Acetoxyethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3- [(Z)-1-propenyl]-3-cephem-4-carboxylate (BMY-28271) is an ester-type prodrug of cephalosporin for oral use. Methods suitable for large scale preparation were investigated. The yield was improved by esterification of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-trityloxyiminoacetamido]cep hem-4-carboxylic acid (11) followed by removal...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1990
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.43.1564